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Fabrication of SnO2–graphene nanocomposite based electrode for sensitive monitoring of anti–Tuberculosis in human fluids

Abstract

We demonstrated a simple and one step optimized achievement of tin oxide–reduced graphene (SnO2–Gr) nanocomposite through simultaneous oxidation and reduction of SnCl2 and graphene oxide (GO). The crystal structure, chemical composition, oxidation state, surface morphology and the average size of the SnO2 nanoparticles in the nanocomposite was discussed. The extent of defect present in the nanocomposite was calculated from the ID/IG ratio. Further, the electrochemical property of SnO2–Gr nanocomposite modified glassy carbon (SnO2–Gr/GC) electrode was studied by CV which produces high electrocatalytic activity and enhances the electrochemical detection ability towards anti tuberculosis agent isoniazide (INH). As fabricated SnO2–Gr/GC electrode reduce the over potential of 610 mV when compare to bare GC and SnO2/GC electrode. The potential optimized amperometric signal exhibited the linear concentration range of INH from 0.1x10-6 M to 8.5x10-4 M with sensitivity of 0.0187 μAμM-1 and limit of detection (LOD) was found to be 6.0×10-8 M, in pulse optimized square wave voltammograme reveals linear concentration range between 1.9x10-8 to 7.2x10-6 M with high sensitivity of 1.098μAμM-1 and LOD was found to 7.2x10-9 M. Moreover the SnO2–Gr/GC electrode was analyzed INH in human urine sample and pharmaceutical tablets in the presence of coexisting interference substances, the SnO2–Gr/GC electrode also exhibited good repeatability, reproducibility and stability, The observed results confirms that the proposed sensor electrode was suitable for INH sensor.

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Supplementary files

Publication details

The article was received on 08 Sep 2017, accepted on 22 Dec 2017 and first published on 05 Jan 2018


Article type: Paper
DOI: 10.1039/C7NJ03411C
Citation: New J. Chem., 2018, Accepted Manuscript
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    Fabrication of SnO2–graphene nanocomposite based electrode for sensitive monitoring of anti–Tuberculosis in human fluids

    J. Santhanalkshmi and K. Rajesh, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C7NJ03411C

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