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Issue 3, 2018
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Lipase catalyzed 1,2-addition of thiols to imines under mild conditions

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Abstract

This is the first report of enzymes used as biocatalysts for a 1,2-sulfur addition. In this study, we describe the synthesis of N,S-acetals using an environmentally friendly process with low catalyst loading and in short reaction times using porcine pancreatic lipase, chymosin, and bovine serum albumin (BSA). The hydrogen bond between the enzyme and the N-Boc imine is a key factor in this reaction.

Graphical abstract: Lipase catalyzed 1,2-addition of thiols to imines under mild conditions

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Publication details

The article was received on 07 Sep 2017, accepted on 19 Dec 2017 and first published on 20 Dec 2017


Article type: Paper
DOI: 10.1039/C7NJ03387G
Citation: New J. Chem., 2018,42, 1642-1645
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    Lipase catalyzed 1,2-addition of thiols to imines under mild conditions

    T. B. Albuquerque, C. D. G. da Silva, A. R. de Oliveira, B. F. dos Santos, B. A. L. da Silva, R. Katla, M. P. D. Rocha and N. L. C. Domingues, New J. Chem., 2018, 42, 1642
    DOI: 10.1039/C7NJ03387G

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