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Synthesis of cubic spherosilicates for self-assembled organic–inorganic biohybrids based on functionalized methacrylates

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Abstract

The aim of this work is to develop an efficient synthetic approach to hexahedral cage-like organic–inorganic siloxane core biohybrids containing side chains fully functionalized by methacrylate groups derived from monomers such as 2-hydroxyethyl methacrylate (HEMA) or ethylene glycol dimethacrylate (EGDMA). The resulting hybrids were characterized using spectroscopic methods (FTIR, 1H, 13C, 29Si NMR), thermogravimetric and DSC analyses, and high resolution mass spectrometry (HR-MS). The obtained compounds, after polycondensation/polymerization reactions, were utilized in constructing 3D macroporous scaffolds which were examined using a scanning electron microscope (SEM). Covalent networks created by fully functionalized cubic spherosilicates can mimic certain biomaterials and constitute sophisticated, highly organized building blocks of complex systems.

Graphical abstract: Synthesis of cubic spherosilicates for self-assembled organic–inorganic biohybrids based on functionalized methacrylates

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Publication details

The article was received on 12 Jul 2017, accepted on 23 Nov 2017 and first published on 23 Nov 2017


Article type: Paper
DOI: 10.1039/C7NJ02533E
Citation: New J. Chem., 2018, Advance Article
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    Synthesis of cubic spherosilicates for self-assembled organic–inorganic biohybrids based on functionalized methacrylates

    Ł. John, M. Janeta and S. Szafert, New J. Chem., 2018, Advance Article , DOI: 10.1039/C7NJ02533E

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