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Reassessment of long circulation via monitoring of integral polymeric nanoparticles justifies a more accurate understanding

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Abstract

Monitoring of payloads results in a biased perception of long circulation of nanoparticles. Instead, herein, the long-circulation effect was re-confirmed by monitoring integral nanoparticles, but circulation was not found to be as long as generally perceived. In contrast, disparate pharmacokinetics were obtained by monitoring a model drug, paclitaxel, highlighting the bias of the conventional protocol.

Graphical abstract: Reassessment of long circulation via monitoring of integral polymeric nanoparticles justifies a more accurate understanding

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Publication details

The article was received on 19 Jan 2018, accepted on 21 Mar 2018 and first published on 22 Mar 2018


Article type: Communication
DOI: 10.1039/C8NH00010G
Citation: Nanoscale Horiz., 2018, Advance Article
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    Reassessment of long circulation via monitoring of integral polymeric nanoparticles justifies a more accurate understanding

    H. He, S. Jiang, Y. Xie, Y. Lu, J. Qi, X. Dong, W. Zhao, Z. Yin and W. Wu, Nanoscale Horiz., 2018, Advance Article , DOI: 10.1039/C8NH00010G

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