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The significance, trafficking and determination of labile iron in cytosol, mitochondrion and lysosome

Abstract

Labile iron pool (LIP) is a pool of chelatable and redox-active iron, not only being essential for a wide variety of metabolic process, but also acting as a catalyst in Fenton reaction, causing the release of hazardous reactive oxygen species (ROS) with potential for inducing oxidative stress and cell damage. The cellular LIP represents the entirety of the every heterogenous sub-pools of iron, not only present in cytosol, but also in mitochondria, lysosomes and nucleus, which all have been detected and characterized by various fluorescent methods. Accumulated evidence indicated that alterations in intracellular LIP can substantially contribute to a variety of injurious processes and initiate pathological development. Herein, we present our understandings on the role of cellular LIP. To fully review LIP, firstly, the significances of cellular labile iron in different subcellular compartments have been presented respectively. And then, the trafficking processes of cellular labile iron between/in cytosol, mitochondria and lysosome have been discussed in detail. Afterwards, the recent progresses in uncovering and assessing the cellular LIP by fluorescent methods have been noted. Overall, the summary may help to comprehensively envision about the important physiological and pathological roles of LIP and shed light on profiling LIP in a real-time and nondestructive manner with the fluorescent methods. Undoubtedly, with the advent and development of iron biology, a better understanding of iron, especially LIP, may also enhance treatments for iron-related diseases.

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Publication details

The article was received on 02 Mar 2018, accepted on 06 Jun 2018 and first published on 07 Jun 2018


Article type: Critical Review
DOI: 10.1039/C8MT00048D
Citation: Metallomics, 2018, Accepted Manuscript
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    The significance, trafficking and determination of labile iron in cytosol, mitochondrion and lysosome

    H. Lv and P. Shang, Metallomics, 2018, Accepted Manuscript , DOI: 10.1039/C8MT00048D

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