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Issue 5, 2018
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Capturing platinum in cisplatin: kinetic reactions with recombinant human apo-metallothionein 1a

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Abstract

cis-Diamminedichloroplatinum(II) (cisplatin), a powerful chemotherapeutic, can incur chemoresistance in cancers, reducing therapeutic success. Metallothioneins (MTs) are suspected of metallodrug interference via ligand removal and metal sequestration. The mechanistic details and reactions rates kobs for the systematic deconstruction of cisplatin by apo-human MT are reported and analysed from mass spectral data.

Graphical abstract: Capturing platinum in cisplatin: kinetic reactions with recombinant human apo-metallothionein 1a

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Publication details

The article was received on 31 Jan 2018, accepted on 17 Apr 2018 and first published on 17 Apr 2018


Article type: Communication
DOI: 10.1039/C8MT00029H
Citation: Metallomics, 2018,10, 713-721
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    Capturing platinum in cisplatin: kinetic reactions with recombinant human apo-metallothionein 1a

    D. L. Wong and M. J. Stillman, Metallomics, 2018, 10, 713
    DOI: 10.1039/C8MT00029H

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