Jump to main content
Jump to site search

Issue 3, 2018
Previous Article Next Article

The teleos of metallo-reduction and metallo-oxidation in eukaryotic iron and copper trafficking

Author affiliations

Abstract

Eukaryotic cells, whether free-living or organismal, rely on metallo-reductases to process environmental ferric iron and cupric copper prior to uptake. In addition, some free-living eukaryotes (e.g. fungi and algae) couple ferri-reduction to ferro-oxidation, a process catalyzed by a small cohort of multi-copper oxidases; in these organisms, the ferric iron product is a ligand for cell iron uptake via a ferric iron permease. In addition to their support of iron uptake in lower eukaryotes, ferroxidases support ferrous iron efflux in Chordata; in this process the release of the ferrous iron from the efflux transporter is catalyzed by its ferroxidation. Last, ferroxidases also catalyze the oxidation of cuprous copper and, as metallo-oxidases, mirror the dual activity of the metallo-reductases. This Perspective examines the teleos of the yin–yang of this redox cycling of iron and copper in their metabolism.

Graphical abstract: The teleos of metallo-reduction and metallo-oxidation in eukaryotic iron and copper trafficking

Back to tab navigation

Publication details

The article was received on 12 Jan 2018, accepted on 21 Feb 2018 and first published on 21 Feb 2018


Article type: Perspective
DOI: 10.1039/C8MT00015H
Citation: Metallomics, 2018,10, 370-377
  •   Request permissions

    The teleos of metallo-reduction and metallo-oxidation in eukaryotic iron and copper trafficking

    D. J. Kosman, Metallomics, 2018, 10, 370
    DOI: 10.1039/C8MT00015H

Search articles by author

Spotlight

Advertisements