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Metallome evolution in ageing C. elegans and a copper stable isotope perspective


Ageing is accompanied by important chemical deregulations resulting in bodily metal imbalances. The way and extent to which these deregulations are associated with ageing processes are however poorly understood and their use as potential biomarkers of ageing has not been investigated. In this study, we report whole-body elementary concentrations and copper and zinc isotopic compositions of Caenorhabditis elegans in ageing wild type (i.e. ‘normal’-lived) and mutant strains (i.e. short and long-lived). We show that strains are characterized by different levels of mutation-related variations such as phosphorous and magnesium as well as zinc isotopic composition. During ageing, strains are affected by elemental age-related variations, such as an increase in calcium and iron concentrations and a decrease of the copper isotopic composition and concentration for long-lived mutants. The deregulated metabolism of copper seems to be connected to ageing probably in association with the production of reactive oxygen species. We emphasize that the copper stable isotope composition could serve in the future as a biomarker of normal or accelerated ageing.

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Publication details

The article was received on 20 Nov 2017, accepted on 15 Feb 2018 and first published on 15 Feb 2018

Article type: Paper
DOI: 10.1039/C7MT00318H
Citation: Metallomics, 2018, Accepted Manuscript
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    Metallome evolution in ageing C. elegans and a copper stable isotope perspective

    L. Sauzéat, A. Laurençon and V. Balter, Metallomics, 2018, Accepted Manuscript , DOI: 10.1039/C7MT00318H

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