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Issue 4, 2018
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A ratiometric iron probe enables investigation of iron distribution within tumour spheroids

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Abstract

Iron dysregulation is implicated in numerous diseases, and iron homeostasis is profoundly influenced by the labile iron pool (LIP). Tools to easily observe changes in the LIP are limited, with calcein AM-based assays most widely used. We describe here FlCFe1, a ratiometric analogue of calcein AM, which also provides the capacity for imaging iron in 3D cell models.

Graphical abstract: A ratiometric iron probe enables investigation of iron distribution within tumour spheroids

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Publication details

The article was received on 25 Oct 2017, accepted on 27 Mar 2018 and first published on 16 Apr 2018


Article type: Communication
DOI: 10.1039/C7MT00297A
Citation: Metallomics, 2018,10, 553-556
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    A ratiometric iron probe enables investigation of iron distribution within tumour spheroids

    I. J. Carney, J. L. Kolanowski, Z. Lim, B. Chekroun, A. G. Torrisi, T. W. Hambley and E. J. New, Metallomics, 2018, 10, 553
    DOI: 10.1039/C7MT00297A

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