Jump to main content
Jump to site search


STAT3 is required for proliferation and exhibits a cell type-specific binding preference in mouse female germline stem cells

Author affiliations

Abstract

LIF-mediated STAT3 signaling is critically involved in stem cells and development. However, its function in mouse female germline cells (FGSCs) remains elusive. In this study, we demonstrated that LIF-induced STAT3 activation contributes to the proliferation and undifferentiation maintenance of mouse FGSCs. Characterization of the STAT3-mediated transcriptional network by intersecting ChIP-seq and RNA-seq datasets revealed 405 direct target genes of STAT3, which are primarily involved in proliferation and germline development. In particular, we observed that STAT3 exhibits a FGSC-specific binding pattern when compared with mouse embryonic stem cells. Taken together, our study reported that the LIF-mediated STAT3 activation is actively involved in FGSCs and functions through a distinctive binding pattern across the FGSC genome. This cell-type specific binding preference provides an insight into understanding the genetic base for STAT3-driven cellular functions in germline stem cells.

Graphical abstract: STAT3 is required for proliferation and exhibits a cell type-specific binding preference in mouse female germline stem cells

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Nov 2017, accepted on 22 Jan 2018 and first published on 12 Feb 2018


Article type: Research Article
DOI: 10.1039/C7MO00084G
Citation: Mol. Omics, 2018, Advance Article
  •   Request permissions

    STAT3 is required for proliferation and exhibits a cell type-specific binding preference in mouse female germline stem cells

    Y. Gu, J. Wu, W. Yang, C. Xia, X. Shi, H. Li, J. Sun, Z. Shao, J. Wu and X. Zhao, Mol. Omics, 2018, Advance Article , DOI: 10.1039/C7MO00084G

Search articles by author

Spotlight

Advertisements