Issue 4, 2018

Crystallographic snapshots of host–guest interactions in drugs@metal–organic frameworks: towards mimicking molecular recognition processes

Abstract

We report a novel metal–organic framework (MOF) featuring functional pores decorated with hydroxyl groups derived from the natural amino acid L-serine, which is able to establish specific interactions of different natures, strengths and directionalities with organic molecules of technological interest, i.e. ascorbic acid, pyridoxine, bupropion and 17-β-estradiol, based on their different sizes and chemical natures. The ability of 1 to distinctly organize guest molecules within its channels, through the concomitant effect of different directing supramolecular host–guest interactions, enables gaining unique insights, by means of single-crystal X-ray crystallography, into the host–guest interactions. These results increase our understanding of molecular recognition processes in MOFs, opening a myriad of potential technological applications in the near future.

Graphical abstract: Crystallographic snapshots of host–guest interactions in drugs@metal–organic frameworks: towards mimicking molecular recognition processes

Supplementary files

Article information

Article type
Communication
Submitted
13 Mar 2018
Accepted
19 Apr 2018
First published
19 Apr 2018

Mater. Horiz., 2018,5, 683-690

Crystallographic snapshots of host–guest interactions in drugs@metal–organic frameworks: towards mimicking molecular recognition processes

M. Mon, R. Bruno, J. Ferrando-Soria, L. Bartella, L. Di Donna, M. Talia, R. Lappano, M. Maggiolini, D. Armentano and E. Pardo, Mater. Horiz., 2018, 5, 683 DOI: 10.1039/C8MH00302E

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