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Tumor-specific disintegratable nanohybrids containing ultrasmall inorganic nanoparticles: From design and improved properties to cancer applications

Abstract

The size of nanoparticles is highly related to their intratumor penetration ability and long-time accumulation-derived toxicity to normal organs. The moderate particle size (50~200 nm) favors the intratumor accumulation, while both the deep penetration into tumor and the quick clearance from the body require particle size to be as small as possible (generally less than 10 nm). How to balance the contradiction regarding particle size is vitally important to enhance cancer therapy efficacy and reduce toxicity, but is still challenging. One of reasonable solutions is to design disintegratable nanohybrids, which are assembled into a desired size of bigger nanoparticle from ultrasmall particles and are also able to disassemble into ultrasmall particles in a responsive/controlled way. Tumor-specific disintegratable nanohybrids containing ultrasmall functional inorganic nanoparticles could achieve long blood circulation and extravasate after reaching the tumor site, they could be triggered by stimuli to disintegrate into small particles in favor of their penetration into deep tumor tissue and their clearance by the body. Moreover, the integration of multiple functional nanoparticles into nanohybrid can significantly amplify their physicochemical performances, enhancing the efficacies of cancer diagnosis and treatment. Herein, this review summarizes the design strategies of tumor-specific disintegratable nanohybrids, indicates their improved properties, and highlights their applications in highly effective diagnosis and treatment of cancer.

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Publication details

The article was received on 10 Dec 2017, accepted on 09 Jan 2018 and first published on 09 Jan 2018


Article type: Review Article
DOI: 10.1039/C7MH01071K
Citation: Mater. Horiz., 2018, Accepted Manuscript
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    Tumor-specific disintegratable nanohybrids containing ultrasmall inorganic nanoparticles: From design and improved properties to cancer applications

    Y. Wang, F. Wang, Y. Shen, Q. He and S. Guo, Mater. Horiz., 2018, Accepted Manuscript , DOI: 10.1039/C7MH01071K

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