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Issue 3, 2018
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Patterned superhydrophobic surfaces to process and characterize biomaterials and 3D cell culture

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Abstract

Microarrays are a technological breakthrough for high-throughput screening of large numbers of assays. We review the evolution of microarray platforms for 3D cell culture to exhibit complex biological environments for tissue engineering, diagnostics and disease models. Patterned microarrays with extreme wettabilities were suggested as a versatile platform for high-throughput assays to generate 3D cell environments, as well as to characterize and analyze biomaterials' properties and cell–cell and cell–biomaterial interactions. Among the emerging HTS approaches, platforms with extreme wettabilities have the potential to revolutionize biomedical research, offering opportunities for drug screening on 3D cell based-systems with high reproducibility, versatility and spatial control.

Graphical abstract: Patterned superhydrophobic surfaces to process and characterize biomaterials and 3D cell culture

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Publication details

The article was received on 24 Oct 2017, accepted on 08 Mar 2018 and first published on 08 Mar 2018


Article type: Review Article
DOI: 10.1039/C7MH00877E
Citation: Mater. Horiz., 2018,5, 379-393
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    Patterned superhydrophobic surfaces to process and characterize biomaterials and 3D cell culture

    A. I. Neto, P. A. Levkin and J. F. Mano, Mater. Horiz., 2018, 5, 379
    DOI: 10.1039/C7MH00877E

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