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pH responsive glycopolymer nanoparticles for targeted delivery of anti-cancer drugs

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Abstract

Over the past decade, there has been a great deal of interest in the integration of nanotechnology and carbohydrates. The advances in glyconanotechnology have allowed the creation of different bioactive glyconanostructures for different types of medical applications, especially for drug delivery and release systems. Therefore, the use of more efficient biocompatible nanocarriers with high loading capacity, low overall toxicity and receptor-mediated endocytosis specificity is still in focus for the enhancement of the therapeutic effect. Conjugation of sugar derivatives onto gold nanoparticles presents unique properties that include a wide array of assembling models and size-related electronic, magnetic and optical properties. Here, pH-responsive drug-conjugated glycopolymer-coated gold nanoparticles were prepared by functionalization of gold nanoparticles with thiol-terminated glycopolymers and then subsequent conjugation of doxorubicin (DOX). Among the four different glycopolymers, their drug release, physicochemical characterization (spectroscopy, particle size and surface charge) and in vitro bioapplications with four different cell lines were compared. As a result, pH-sensitive drug delivery via sugar-coated AuNPs was performed thanks to hydrazone linkages between glycopolymers and DOX. Comparative viability tests also demonstrated the efficiency of glycopolymer–DOX conjugates by fluorescence cell imaging. The obtained results reveal that AuNP homoglycopolymer DOX conjugates (P4D) have significant potential, especially in human neuroblastoma cells in comparison to cervical cancer cells and lung cancer cells.

Graphical abstract: pH responsive glycopolymer nanoparticles for targeted delivery of anti-cancer drugs

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Publication details

The article was received on 03 Sep 2017, accepted on 18 Oct 2017 and first published on 18 Oct 2017


Article type: Paper
DOI: 10.1039/C7ME00086C
Citation: Mol. Syst. Des. Eng., 2018, Advance Article
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    pH responsive glycopolymer nanoparticles for targeted delivery of anti-cancer drugs

    G. Yilmaz, E. Guler, C. Geyik, B. Demir, M. Ozkan, D. Odaci Demirkol, S. Ozcelik, S. Timur and C. R. Becer, Mol. Syst. Des. Eng., 2018, Advance Article , DOI: 10.1039/C7ME00086C

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