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Issue 5, 2018
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Reduction–rebridging strategy for the preparation of ADPN-based antibody–drug conjugates

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Abstract

The reduction–rebridging strategy is a powerful method for the preparation of stable and homogeneous antibody–drug conjugates (ADCs). In this communication, we describe the development of the arylene-dipropiolonitrile (ADPN) functional group for the rebridging of reduced disulphide bonds and its application in the preparation of potent and selective ADCs.

Graphical abstract: Reduction–rebridging strategy for the preparation of ADPN-based antibody–drug conjugates

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Publication details

The article was received on 14 Mar 2018, accepted on 07 Apr 2018 and first published on 20 Apr 2018


Article type: Research Article
DOI: 10.1039/C8MD00141C
Citation: Med. Chem. Commun., 2018,9, 827-830
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    Reduction–rebridging strategy for the preparation of ADPN-based antibody–drug conjugates

    O. Koniev, I. Dovgan, B. Renoux, A. Ehkirch, J. Eberova, S. Cianférani, S. Kolodych, S. Papot and A. Wagner, Med. Chem. Commun., 2018, 9, 827
    DOI: 10.1039/C8MD00141C

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