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Issue 5, 2018
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The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin

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Abstract

A dozen oxime, hydrazine and hydrazide derivatives of platensimycin (PTM) analogues were synthesized, some of which showed strong antibacterial activities and were shown to be stable under the bioassay conditions. Docking analysis revealed that they have certain new interactions with β-ketoacyl-[acyl carrier protein] synthase II (FabF), suggesting that Schiff base formation on its terpene scaffold is an effective strategy to diversify PTM structure.

Graphical abstract: The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin

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Publication details

The article was received on 11 Feb 2018, accepted on 01 Mar 2018 and first published on 06 Mar 2018


Article type: Research Article
DOI: 10.1039/C8MD00081F
Citation: Med. Chem. Commun., 2018,9, 789-794
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    The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin

    Y. Deng, D. Kang, J. Shi, W. Zhou, A. Sun, J. Ju, X. Zhu, B. Shen, Y. Duan and Y. Huang, Med. Chem. Commun., 2018, 9, 789
    DOI: 10.1039/C8MD00081F

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