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Approaches to target tractability assessment – a practical perspective

Abstract

Abstract. The assessment of the suitability of novel targets to intervention by different modalities, e.g. small molecules or antibodies, is increasingly seen as important in helping to select the most progressable targets at the outset of a drug discovery project. This perspective considers differing aspects of tractability and how it can be assessed using in silico and experimental approaches. We also share some of our experiences in using these approaches.

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Publication details

The article was received on 15 Dec 2017, accepted on 13 Feb 2018 and first published on 14 Feb 2018


Article type: Review Article
DOI: 10.1039/C7MD00633K
Citation: Med. Chem. Commun., 2018, Accepted Manuscript
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    Approaches to target tractability assessment – a practical perspective

    K. Brown, M. M. Hann, A. Lakdawala Shah, R. Santos, P. J. Thomas and K. Todd, Med. Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C7MD00633K

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