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Issue 2, 2018
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Antiproliferative activity of novel isatinyl/indanyl nitrones (INs) as potential spin trapping agents of free radical intermediates

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Abstract

A series of ketonitrones derived from isatin and indanone (INs) were synthesized and evaluated for their antiproliferative activities against several human cancer cell lines. Then, the antioxidant properties of these substrates were measured by the DPPH test to report their biological activity in terms of their spin trapping action. In particular, one substrate has showed very high biological and scavenging activity, probably due to the strong correlation between its spin trapping activity and structure.

Graphical abstract: Antiproliferative activity of novel isatinyl/indanyl nitrones (INs) as potential spin trapping agents of free radical intermediates

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Publication details

The article was received on 23 Oct 2017, accepted on 11 Dec 2017 and first published on 20 Dec 2017


Article type: Research Article
DOI: 10.1039/C7MD00537G
Citation: Med. Chem. Commun., 2018,9, 299-304
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    Antiproliferative activity of novel isatinyl/indanyl nitrones (INs) as potential spin trapping agents of free radical intermediates

    L. Maiuolo, G. Feriotto, V. Algieri, M. Nardi, B. Russo, M. L. Di Gioia, E. Furia, M. A. Tallarida, C. Mischiati and A. De Nino, Med. Chem. Commun., 2018, 9, 299
    DOI: 10.1039/C7MD00537G

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