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Narrow-spectrum antibacterial agents

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Abstract

While broad spectrum antibiotics play an invaluable role in the treatment of bacterial infections, there are some drawbacks to their use, namely selection for and spread of resistance across multiple bacterial species, and the detrimental effect they can have upon the host microbiome. If the causative agent of the infection is known, the use of narrow-spectrum antibacterial agents has the potential to mitigate some of these issues. This review outlines the advantages and challenges of narrow-spectrum antibacterial agents, discusses the progress that has been made toward developing diagnostics to enable their use, and describes some of the narrow-spectrum antibacterial agents currently being investigated against some of the most clinically important bacteria including Clostridium difficile, Mycobacterium tuberculosis and several ESKAPE pathogens.

Graphical abstract: Narrow-spectrum antibacterial agents

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Publication details

The article was received on 17 Oct 2017, accepted on 02 Nov 2017 and first published on 06 Nov 2017


Article type: Review Article
DOI: 10.1039/C7MD00528H
Citation: Med. Chem. Commun., 2018, Advance Article
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    Narrow-spectrum antibacterial agents

    R. J. Melander, D. V. Zurawski and C. Melander, Med. Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7MD00528H

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