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MicroRNAs as novel endogenous targets for regulation and therapeutic treatments

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Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that have been identified as key endogenous biomolecules that are able to regulate gene expression at the post-transcriptional level. The abnormal expression or function of miRNAs has been demonstrated to be closely related to the occurrence or development of various human diseases, including cancers. Regulation of these abnormal miRNAs thus holds great promise for therapeutic treatments. In this review, we summarize exogenous molecules that are able to regulate endogenous miRNAs, including small molecule regulators of miRNAs and synthetic oligonucleotides. Strategies for screening small molecule regulators of miRNAs and recently reported small molecules are introduced and summarized. Synthetic oligonucleotides including antisense miRNA oligonucleotides and miRNA mimics, as well as delivery systems for these synthetic oligonucleotides to enter cells, that regulate endogenous miRNAs are also summarized. In addition, we discuss recent applications of these small molecules and synthetic oligonucleotides in therapeutic treatments. Overall, this review aims to provide a brief synopsis of recent achievements of using both small molecule regulators and synthetic oligonucleotides to regulate endogenous miRNAs and achieve therapeutic outcomes. We envision that these regulators of endogenous miRNAs will ultimately contribute to the development of new therapies in the future.

Graphical abstract: MicroRNAs as novel endogenous targets for regulation and therapeutic treatments

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Publication details

The article was received on 02 Jun 2017, accepted on 10 Dec 2017 and first published on 11 Dec 2017


Article type: Review Article
DOI: 10.1039/C7MD00285H
Citation: Med. Chem. Commun., 2018, Advance Article
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    MicroRNAs as novel endogenous targets for regulation and therapeutic treatments

    W. Cha, R. Fan, Y. Miao, Y. Zhou, C. Qin, X. Shan, X. Wan and T. Cui, Med. Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7MD00285H

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