Issue 22, 2018

On-chip photodynamic therapy – monitoring cell metabolism using electrochemical microsensors

Abstract

We introduce a new system which combines metabolic monitoring using electrochemical microsensors with photodynamic therapy on-chip for the first time. Oxygen consumption of T-47D breast cancer cells was measured during therapy with protoporphyrin IX. We determined the efficacy of the therapy and revealed its recovery effects, which underlines the high relevance of continuous monitoring.

Graphical abstract: On-chip photodynamic therapy – monitoring cell metabolism using electrochemical microsensors

Article information

Article type
Communication
Submitted
02 Aug 2018
Accepted
29 Sep 2018
First published
02 Oct 2018

Lab Chip, 2018,18, 3353-3360

On-chip photodynamic therapy – monitoring cell metabolism using electrochemical microsensors

J. Marzioch, J. Kieninger, A. Weltin, H. Flamm, K. Aravindalochanan, J. A. Sandvik, E. O. Pettersen, Q. Peng and G. A. Urban, Lab Chip, 2018, 18, 3353 DOI: 10.1039/C8LC00799C

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