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Issue 8, 2018
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Binary centrifugal microfluidics enabling novel, digital addressable functions for valving and routing

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Abstract

Centrifugal microfluidics or lab-on-a-disc (LOAD) is a promising branch of lab-on-a-chip or microfluidics. Besides effective fluid transportation and inherently available density-based sample separation in centrifugal microfluidics, uniform actuation of flow on the disc makes the platform compact and scalable. However, the natural radially outward centrifugal force in a LOAD system limits its capacity to perform complex fluid manipulation steps. In order to increase the fluid manipulation freedom and integration capacity of the LOAD system, we propose a binary centrifugal microfluidics platform. With the help of Euler force, our platform allows free switching of both left and right states based on a rather simple mechanical structure. The periodical switching of state would provide a “clock” signal for a sequence of droplet binary logic operations. With the binary state platform and the “clock” signal, we can accurately handle the droplet separately in each time step with a maximum main frequency of about 10 S s−1 (switching per second). Apart from droplet manipulations such as droplet generation and metering, we also demonstrate a series of droplet logic operations, such as binary valving, droplet routing and digital addressable droplet storage. Furthermore, complex bioassays such as the Bradford assay and DNA purification assay are demonstrated on a binary platform, which is totally impossible for a traditional LOAD system. Our binary platform largely improves the capability for logic operation on the LOAD platform, and it is a simple and promising approach for microfluidic lab-on-a-disc large-scale integration.

Graphical abstract: Binary centrifugal microfluidics enabling novel, digital addressable functions for valving and routing

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Publication details

The article was received on 10 Jan 2018, accepted on 06 Mar 2018 and first published on 08 Mar 2018


Article type: Paper
DOI: 10.1039/C8LC00026C
Citation: Lab Chip, 2018,18, 1197-1206
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    Binary centrifugal microfluidics enabling novel, digital addressable functions for valving and routing

    G. Wang, J. Tan, M. Tang, C. Zhang, D. Zhang, W. Ji, J. Chen, H. Ho and X. Zhang, Lab Chip, 2018, 18, 1197
    DOI: 10.1039/C8LC00026C

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