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Anodic benzylic C(sp3)–H amination: unified access to pyrrolidines and piperidines

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Abstract

An electrochemical aliphatic C–H amination strategy was developed to access the important heterocyclic motifs of pyrrolidines and piperidines within a uniform reaction protocol. The mechanism of this unprecedented C–H amination strategy involves anodic C–H activation to generate a benzylic cation, which is efficiently trapped by a nitrogen nucleophile. The applicability of the process is demonstrated for 40 examples comprising both 5- and 6-membered ring formations.

Graphical abstract: Anodic benzylic C(sp3)–H amination: unified access to pyrrolidines and piperidines

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Publication details

The article was received on 06 May 2018, accepted on 08 Jun 2018 and first published on 13 Jun 2018


Article type: Communication
DOI: 10.1039/C8GC01411F
Citation: Green Chem., 2018, Advance Article
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    Anodic benzylic C(sp3)–H amination: unified access to pyrrolidines and piperidines

    S. Herold, D. Bafaluy and K. Muñiz, Green Chem., 2018, Advance Article , DOI: 10.1039/C8GC01411F

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