Jump to main content
Jump to site search

Issue 13, 2018
Previous Article Next Article

Sequential (3 + 2) cycloaddition and (5 + n) annulation for modular synthesis of dihydrobenzoxazines, tetrahydrobenzoxazepines and tetrahydrobenzoxazocines

Author affiliations

Abstract

A two-step method for the (3 + 2) cycloaddition of azomethine ylides followed by a double SN2 substitution-based (5 + n) annulation is introduced for the modular synthesis of dihydrobenzoxazine, tetrahydrobenzoxazepine and tetrahydrobenzoxazocine derivatives. After a quick water wash without further purification, the (3 + 2) cycloaddition intermediates were used for the (5 + n) annulation to afford products. Green chemistry metrics analysis of the synthetic processes provided favorable results.

Graphical abstract: Sequential (3 + 2) cycloaddition and (5 + n) annulation for modular synthesis of dihydrobenzoxazines, tetrahydrobenzoxazepines and tetrahydrobenzoxazocines

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Apr 2018, accepted on 11 Jun 2018 and first published on 12 Jun 2018


Article type: Paper
DOI: 10.1039/C8GC01099D
Citation: Green Chem., 2018,20, 3134-3139
  •   Request permissions

    Sequential (3 + 2) cycloaddition and (5 + n) annulation for modular synthesis of dihydrobenzoxazines, tetrahydrobenzoxazepines and tetrahydrobenzoxazocines

    A. Muthengi, X. Zhang, G. Dhawan, W. Zhang, F. Corsini and W. Zhang, Green Chem., 2018, 20, 3134
    DOI: 10.1039/C8GC01099D

Search articles by author

Spotlight

Advertisements