Issue 11, 2018

Transition metal free oxygenation of 8-aminoquinoline amides in water

Abstract

The oxygenation of 8-aminoquinoline amides by benzoyl peroxide at the C5 position in water is developed in the absence of a transition metal catalyst, affording the desired products in moderate to good yields of up to 88%. Mechanism studies reveal that the reaction would involve a radical process.

Graphical abstract: Transition metal free oxygenation of 8-aminoquinoline amides in water

Supplementary files

Article information

Article type
Communication
Submitted
18 Jan 2018
Accepted
12 Apr 2018
First published
13 Apr 2018

Green Chem., 2018,20, 2472-2476

Transition metal free oxygenation of 8-aminoquinoline amides in water

X. Yao, X. Weng, K. Wang, H. Xiang and X. Zhou, Green Chem., 2018, 20, 2472 DOI: 10.1039/C8GC00191J

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