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Issue 11, 2018
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Transition metal free oxygenation of 8-aminoquinoline amides in water

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Abstract

The oxygenation of 8-aminoquinoline amides by benzoyl peroxide at the C5 position in water is developed in the absence of a transition metal catalyst, affording the desired products in moderate to good yields of up to 88%. Mechanism studies reveal that the reaction would involve a radical process.

Graphical abstract: Transition metal free oxygenation of 8-aminoquinoline amides in water

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Publication details

The article was received on 18 Jan 2018, accepted on 12 Apr 2018 and first published on 13 Apr 2018


Article type: Communication
DOI: 10.1039/C8GC00191J
Citation: Green Chem., 2018,20, 2472-2476
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    Transition metal free oxygenation of 8-aminoquinoline amides in water

    X. Yao, X. Weng, K. Wang, H. Xiang and X. Zhou, Green Chem., 2018, 20, 2472
    DOI: 10.1039/C8GC00191J

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