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Flavin–iodine coupled organocatalysis for the aerobic oxidative direct sulfenylation of indoles with thiols under mild conditions

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Abstract

A unique coupled redox organocatalysis system using flavin and iodine catalysts efficiently promoted the metal-free aerobic oxidative direct sulfenylation of indoles with thiols at ambient temperature without any sacrificial reagents, except environmentally benign molecular oxygen. Biomimetic flavin catalysis plays multiple roles in aerobic oxidative transformations, not only regenerating I2 from in situ generated I, but also converting thiols into disulfides.

Graphical abstract: Flavin–iodine coupled organocatalysis for the aerobic oxidative direct sulfenylation of indoles with thiols under mild conditions

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Publication details

The article was received on 12 Jan 2018, accepted on 05 Feb 2018 and first published on 05 Feb 2018


Article type: Communication
DOI: 10.1039/C8GC00117K
Citation: Green Chem., 2018, Advance Article
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    Flavin–iodine coupled organocatalysis for the aerobic oxidative direct sulfenylation of indoles with thiols under mild conditions

    R. Ohkado, T. Ishikawa and H. Iida, Green Chem., 2018, Advance Article , DOI: 10.1039/C8GC00117K

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