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Issue 6, 2018
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Catalyst-free nucleophilic addition reactions of silyl glyoxylates in water

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Abstract

A novel catalyst-free addition of thiols to silyl glyoxylates was developed in water, providing an efficient route for the synthesis of α-hydroxysilanes. In the activation of silyl glyoxylates, hydrogen bonding is critical to the reaction, and rate acceleration was observed in water. Moreover, the competing Brook rearrangement was significantly suppressed with the assistance of water.

Graphical abstract: Catalyst-free nucleophilic addition reactions of silyl glyoxylates in water

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Publication details

The article was received on 17 Dec 2017, accepted on 16 Feb 2018 and first published on 19 Feb 2018


Article type: Communication
DOI: 10.1039/C7GC03775A
Citation: Green Chem., 2018,20, 1228-1232
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    Catalyst-free nucleophilic addition reactions of silyl glyoxylates in water

    M. Han, J. Lin, W. Li, W. Luan, P. Mai and Y. Zhang, Green Chem., 2018, 20, 1228
    DOI: 10.1039/C7GC03775A

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