Issue 3, 2018

Metal-free regioselective hydrochlorination of unactivated alkenes via a combined acid catalytic system

Abstract

A combined acid HCl/DMPU-acetic acid catalytic system was used in the hydrochlorination of a wide range of unactivated alkenes. This hydrochlorination strategy is remarkably greener than previous reported methods in terms of high atom efficiency, no toxic waste generated and metal-free process. The higher efficiency, compared with other commercially available HCl reagents, was augmented by the good regioselectivity and functionality tolerance found. A stepwise mechanism for this hydrochlorination process was proposed based on kinetic studies.

Graphical abstract: Metal-free regioselective hydrochlorination of unactivated alkenes via a combined acid catalytic system

Supplementary files

Article information

Article type
Paper
Submitted
06 Dec 2017
Accepted
31 Dec 2017
First published
02 Jan 2018

Green Chem., 2018,20, 680-684

Metal-free regioselective hydrochlorination of unactivated alkenes via a combined acid catalytic system

S. Liang, G. B. Hammond and B. Xu, Green Chem., 2018, 20, 680 DOI: 10.1039/C7GC03665E

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