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Facile synthesis of 1,4-diketones via three-component reactions of α-ketoaldehyde, 1,3-dicarbonyl compound, and a nucleophile in water

Abstract

Three-component reactions of alkylglyoxals, 1,3-dicarbonyl compounds, and a nucleophile were performed under aqueous and catalyst-free conditions, which produced 1,4-diketone scaffolds in a straightforward way. Many compounds, such as indole, azaindole, pyrrole, 2-methylfuran, N,N-dimethylaniline, N-methylaniline, thiophenol, and benzyl mercaptan, were all able to act as nucleophiles to react with alkylglyoxal and 1,3-dicarbonyl compound. Mechanim of this reaction was also investigated. The obtained 1,4-diketones can be easily converted to many valuable chemicals.

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Publication details

The article was received on 04 Dec 2017, accepted on 05 Feb 2018 and first published on 06 Feb 2018


Article type: Paper
DOI: 10.1039/C7GC03644B
Citation: Green Chem., 2018, Accepted Manuscript
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    Facile synthesis of 1,4-diketones via three-component reactions of α-ketoaldehyde, 1,3-dicarbonyl compound, and a nucleophile in water

    J. Yang, F. Mei, S. Fu and Y. Gu, Green Chem., 2018, Accepted Manuscript , DOI: 10.1039/C7GC03644B

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