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Base-catalysed [3 + 2] cycloaddition of propargylamines and aldehydes to substituted furans

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Abstract

A base-catalysed [3 + 2] cycloaddition reaction of propargylamines and aldehydes for the regiospecific synthesis of substituted furans under metal-free conditions is developed. Propargylamines are used as allenyl anion equivalents and applied in [3 + 2] cycloaddition reactions with aldehydes. Various substituted furans are provided up to 91% yield for 28 examples.

Graphical abstract: Base-catalysed [3 + 2] cycloaddition of propargylamines and aldehydes to substituted furans

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Publication details

The article was received on 01 Dec 2017, accepted on 04 Jan 2018 and first published on 04 Jan 2018


Article type: Communication
DOI: 10.1039/C7GC03618C
Citation: Green Chem., 2018, Advance Article
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    Base-catalysed [3 + 2] cycloaddition of propargylamines and aldehydes to substituted furans

    J. Shen, J. Zhao, B. Hu, Y. Chen, L. Wu, Q. You and L. Zhao, Green Chem., 2018, Advance Article , DOI: 10.1039/C7GC03618C

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