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Issue 4, 2018
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Zinc oxide-NP catalyzed direct indolation of in situ generated bioactive tryptanthrin

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Abstract

A ZnO-NP catalyzed direct indolation of in situ generated tryptanthrin via C–H functionalization and C–C bond formation has been developed. This novel and greener approach has been effectively utilized to accomplish the synthesis of 6-hydroxy-6-(1H-indol-3-yl)indolo[2,1-b]quinazolin-12(6H)-one derivatives in good to excellent yields with high product selectivity. Besides the in situ approach, a direct indolation of tryptanthrin has also been developed.

Graphical abstract: Zinc oxide-NP catalyzed direct indolation of in situ generated bioactive tryptanthrin

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Publication details

The article was received on 20 Nov 2017, accepted on 01 Jan 2018 and first published on 03 Jan 2018


Article type: Communication
DOI: 10.1039/C7GC03479B
Citation: Green Chem., 2018,20, 822-826
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    Zinc oxide-NP catalyzed direct indolation of in situ generated bioactive tryptanthrin

    B. Rai, R. D. Shukla and A. Kumar, Green Chem., 2018, 20, 822
    DOI: 10.1039/C7GC03479B

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