Jump to main content
Jump to site search


HMF in multicomponent reactions: utilization of 5-hydroxymethylfurfural (HMF) in the Biginelli reaction

Author affiliations

Abstract

The use of the renewable platform molecule 5-hydroxymethylfurfural (HMF) in the multi-component Biginelli reaction has been investigated. Multicomponent reactions (MCR) using HMF offer straightforward access to novel fine chemicals. However, the peculiar reactivity and lower stability of HMF have limited its use in such strategies. In this paper, we report our results on the use of HMF in 3-component Biginelli reactions, leading in one single step to a series of functionalized dihydropyrimidinones obtained in moderate to good yields, with a broad substrate scope of 1,3-dicarbonyl compounds and urea building blocks. This is the first report on the use of HMF in this reaction. The CH2OH motif found in HMF provides useful functionalization for the target molecules, which cannot be offered by simpler aldehydes such as furfural.

Graphical abstract: HMF in multicomponent reactions: utilization of 5-hydroxymethylfurfural (HMF) in the Biginelli reaction

Back to tab navigation

Supplementary files

Publication details

The article was received on 13 Nov 2017, accepted on 05 Dec 2017 and first published on 11 Dec 2017


Article type: Paper
DOI: 10.1039/C7GC03425C
Citation: Green Chem., 2018, Advance Article
  •   Request permissions

    HMF in multicomponent reactions: utilization of 5-hydroxymethylfurfural (HMF) in the Biginelli reaction

    W. Fan, Y. Queneau and F. Popowycz, Green Chem., 2018, Advance Article , DOI: 10.1039/C7GC03425C

Search articles by author

Spotlight

Advertisements