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Visible-Light-Promoted Intramolecular C–H Amination in Aqueous Solution: Synthesis of Carbazoles

Abstract

An effective and operationally simple protocol is reported for the synthesis of versatile carbazoles. With water as co-solvent, visible-light rather than various metals is used to facilitate conversion of readily available 2-azidobiphenyls under mild conditions. Various functionalized bioactive natural alkaloids, such as glycoborine, clausine C, clausine L, clausine H and clauszoline K were synthesized efficiently with nitrogen as sole byproduct. The reaction could be performed in water, acidic or alkaline buffer solutions, showing its potential for applications in biochemistry.

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Publication details

The article was received on 10 Nov 2017, accepted on 08 Feb 2018 and first published on 09 Feb 2018


Article type: Paper
DOI: 10.1039/C7GC03392C
Citation: Green Chem., 2018, Accepted Manuscript
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    Visible-Light-Promoted Intramolecular C–H Amination in Aqueous Solution: Synthesis of Carbazoles

    L. Yang, Y. Zhang, X. Zou, H. Lu and G. Li, Green Chem., 2018, Accepted Manuscript , DOI: 10.1039/C7GC03392C

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