Jump to main content
Jump to site search


Catalyst- and solvent-free bisphosphinylation of isothiocyanates: a practical method for the synthesis of bisphosphinoylaminomethanes

Author affiliations

Abstract

A general and convenient double addition of phosphine oxides to isothiocyanates is described. It is a practically useful protocol for the construction of bisphosphinoylaminomethanes. The reaction can be carried out smoothly under metal- and solvent-free conditions. It also features a broad substrate scope, simple operation and purification. A possible mechanism involving a tandem double nucleophilic addition/H2S elimination/in situ imine reduction process is proposed.

Graphical abstract: Catalyst- and solvent-free bisphosphinylation of isothiocyanates: a practical method for the synthesis of bisphosphinoylaminomethanes

Back to tab navigation

Supplementary files

Publication details

The article was received on 14 Oct 2017, accepted on 27 Nov 2017 and first published on 27 Nov 2017


Article type: Communication
DOI: 10.1039/C7GC03101G
Citation: Green Chem., 2018, Advance Article
  •   Request permissions

    Catalyst- and solvent-free bisphosphinylation of isothiocyanates: a practical method for the synthesis of bisphosphinoylaminomethanes

    L. Wen, Y. Sun, J. Zhang, W. Guo and M. Li, Green Chem., 2018, Advance Article , DOI: 10.1039/C7GC03101G

Search articles by author

Spotlight

Advertisements