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Quality assessment of Penthorum chinense Pursh through multicomponent qualification and fingerprint, chemometric, and antihepatocarcinoma analyses

Abstract

An efficient method combined with fingerprint and chemometric analyses was developed to evaluate the quality of the Traditional Chinese Medicine plant Penthorum chinense Pursh. Nine samples were collected from different regions during different harvest periods, and 17 components in extracts were simultaneously examined to assess quality by high-performance liquid chromatography. Hepatoprotective effects of components were investigated by assessing inhibition of SMMC-7721 cell growth. The results indicated that quality control method was accurate, stable, and reliable, and hierarchical heat-map cluster and principle component analyses confirmed that classification of all nine samples was consistent. Quercetin and ellagitannins including pinocembrin-7-O-[3’’-O-galloyl-4’’,6’’-hexahydroxydiphenoyl]-β- glucose (PGHG), thonningianin A, thonningianin B, and other flavonoids were abundant in extracts, and contributed significantly to the hepatoprotective effects.

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Publication details

The article was received on 19 Apr 2018, accepted on 29 May 2018 and first published on 31 May 2018


Article type: Paper
DOI: 10.1039/C8FO00754C
Citation: Food Funct., 2018, Accepted Manuscript
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    Quality assessment of Penthorum chinense Pursh through multicomponent qualification and fingerprint, chemometric, and antihepatocarcinoma analyses

    Z. Sun, Y. Zhang, F. Zhang, J. Zhang, G. Zheng, L. Tan, C.-Z. Wang, L. Zhou, Q. Zhang and C. Yuan, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO00754C

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