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Dietary fatty acid composition impacts plasma fatty acid ethanolamide levels and body composition in Golden Syrian hamsters

Abstract

Fatty acid ethanolamides (FAEs) are a class of lipid amides that regulate numerous pathophysiological functions. To date, pharmacological research in this area has focused on the endocannabinoid system, metabolic pathways, and biological significance of FAEs; however, limited nutritional studies have been conducted to understand the actions of FAEs on food intake and their role on overall body composition. Therefore, the present study was designed with the hypothesis that high C18:1n9 will attenuate the food consumption in Golden Syrian male hamsters (n = 105). Moreover, long-term (two months) effects of feeding hamsters various dietary oil blends, namely, C+S, 25:75 corn oil:n9 safflower oil; F+S, 25:75 flaxseed oil:n6 safflower oil; H+DHA, 85:15 H:docosahexaenoic acid; H+EPA, 85:15 H:eicosapentaenoic acid; HOCO, high oleic canola oil; OO, olive oil; RC, regular canola oil were investigated on plasma levels of seven different FAEs and FA composition, respectively. A further objective was to characterize the actions of these diets on energy expenditure and overall body composition to determine if dietary FA composition affects diet-induced obesity (DIO). Results show that dietary FA directly influenced plasma FA and FAE levels, with marked increases (p<0.05) observed in plasma C18:1n9 levels after high oleic canola oil (HOCO), and olive oil (OO) treatments. Correspondingly, the most elevated plasma oleoylethanolamide (OEA) levels were observed with HOCO and OO treatments, which also decreased (p<0.05) food intake by ~ 8% when compared with H+EPA dietary treatment when measured at the endpoint. Diminished food intake subsequent to HOCO and OO feeding may have resulted from increased OEA concentrations, demonstrating the anorexic properties of the high C18:1n9 dietary components. No differences were observed across OO, HOCO, and HOCO diets with omega-3 FA blends in terms of body composition, energy expenditure, plasma C18:1n9, or OEA concentrations. Based on these findings, we conclude that the addition of HOCO to diets aids in the reduction of food intake, which may contribute to the maintenance of healthy body weight.

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Publication details

The article was accepted on 12 May 2018 and first published on 14 May 2018


Article type: Paper
DOI: 10.1039/C8FO00621K
Citation: Food Funct., 2018, Accepted Manuscript
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    Dietary fatty acid composition impacts plasma fatty acid ethanolamide levels and body composition in Golden Syrian hamsters

    J. Sihag and P. J. H. Jones, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO00621K

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