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Thymus pulegioides L. as a rich source of antioxidant, anti-proliferative and neuroprotective phenolic compounds

Abstract

The potential of Thymus pulegioides L. as an alternative and valuable source of functional ingredients has been assessed. For this purpose, the phenolic constituents profiles and the antioxidant, anti-proliferative, neuroprotective, anti-aging and anti-diabetic activities of both T. pulegioides aqueous decoctions (AD) and hydro-ethanolic extracts (HE) were studied and compared for the first time. Rosmarinic acid was the main phenolic compound, accounting for 35.2% or 47.8% of total identified phenols in AD or HE, respectively (58.5 and 151.9 mg/g extract). Further, high amounts of luteolin-O-hexuronide (AD: 39.9±2.5 mg/g, HE: 60.8±7.0 mg/g), eriodictyol-O-hexuronide (AD: 19.9±2.5 mg/g, HE: 26.8±7.0 mg/g) and chrysoeriol hexoside (AD: 23.5±0.7 mg/g, HE: 16.0±0.7 mg/g) were found. Both extracts showed significant in vitro antioxidant activity, anti-proliferative activity against Caco-2 cells (IC50 82.25 g/mL and 105.44 g/mL, AD and HE, respectively) while reduced hepatotoxicity (HepG2 cells). In general, both T. pulegioides extracts showed poor anti-diabetic activity, moderate anti-aging effect and high neuroprotective activity with both AD and HE extracts, at 0.5 mg/mL, showing an 80% inhibition of acetylcholinesterase activity and 94% inhibition of the tyrosinase activity. The present study highlights the important potential of this herb as a functional food ingredient.

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Publication details

The article was received on 11 Mar 2018, accepted on 05 Jun 2018 and first published on 06 Jun 2018


Article type: Paper
DOI: 10.1039/C8FO00456K
Citation: Food Funct., 2018, Accepted Manuscript
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    Thymus pulegioides L. as a rich source of antioxidant, anti-proliferative and neuroprotective phenolic compounds

    M. Taghouti, C. A. Martins-Gomes, J. Schäfer, L. M. Félix, J. A. Santos, M. Bunzel, F. M. Nunes and A. M. Silva, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO00456K

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