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Strain-specific characters of Lactobacillus plantarum for prevention of Salmonella infection

Abstract

Salmonella is a common food-born pathogen, and lactobacilli have great potential to protect against Salmonella infections as dietary supplement in functional foods. The aim of this study was to investigate the strain-specific properties and the involved mechanisms of Lactobacillus plantarum on prevention against Salmonella infection. Mice were pretreated with mixed strains or single strain of Lactobacillus plantarum for 10 d before challenge with Salmonella Typhimurium SL1344, and the survival rates showed that lactobacilli exerted strain-specific properties in preventing Salmonella infection. Then, in vitro and in vivo studies were carried out to investigate the involved mechanism of the strain-specific properties. Results showed that different Lactobacillus plantarum strains had different effects on inhibiting Salmonella growth, preventing adhesion and invasion of pathogens to epithelial cells, and enhancing immune responses. The present results demonstrated strain-specific characters of probiotics to prevent against Salmonella infection and suggested their underlying mechanisms.

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Publication details

The article was received on 23 Feb 2018, accepted on 08 Jun 2018 and first published on 14 Jun 2018


Article type: Paper
DOI: 10.1039/C8FO00365C
Citation: Food Funct., 2018, Accepted Manuscript
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    Strain-specific characters of Lactobacillus plantarum for prevention of Salmonella infection

    J. Liu, D. Hu, Y. Chen, H. Huang, H. Zhang, J. Zhao, Z. Gu and W. Chen, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO00365C

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