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Immunomodulatory activity and mechanism of docosahexenoic acid (DHA) on immunosuppression mice models

Abstract

In this study, the immunomodulatory activity of docosahexaenoic acid (DHA) on the immunosuppressive BALB/c mice model and its molecular mechanism were elucidated. It was found that the weight indexes of spleens and thymus were significantly increased by DHA (44.0 mg· kg-1 and 88.0 mg· kg-1) treatment in prevention or cure groups. The result of macrophages showed that DHA (44.0 mg· kg-1 and 88.0 mg· kg-1) could promote the proliferation and phagocytosis activity of macrophages in prevention or cure groups. In addition, DHA could activate macrophages by the G-protein cou-pled cell membrane receptor GPR120- Mitogen-Activated Protein Kinases (MAPKs) -nuclear factor κB (NF-κB) p65 pathway in vivo. The result of spleen showed that DHA (44.0 mg· kg-1 and 88.0 mg· kg-1) could promote the proliferation of spleen cells, the natural killer (NK) cells activity in vivo. In prevention or cure groups, quantitative real-time polymerase chain reaction (qRT-PCR) re-sults revealed that DHA (44.0 mg· kg-1 and 88.0 mg· kg-1) could enhance the production of cytokines IL-1β, IL-2, TNF-α and IFN-γ in the spleen of immunosuppressive mice. The HE (hematoxylin and eosin) stained histopathological images showed that DHA could repair the damage inducing by CTX in the spleen cells of prevention or cure groups. These results suggested that DHA has a remarkable immunomodulatory activity on the immunosuppressive mice model in prevention or cure groups.

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Publication details

The article was received on 08 Feb 2018, accepted on 28 Apr 2018 and first published on 04 May 2018


Article type: Paper
DOI: 10.1039/C8FO00269J
Citation: Food Funct., 2018, Accepted Manuscript
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    Immunomodulatory activity and mechanism of docosahexenoic acid (DHA) on immunosuppression mice models

    L. Han, H. Lei, Z. Tian, X. Wang, D. Cheng and C. Wang, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO00269J

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