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The effects of maternal advanced glycation end products-rich diet on somatic features, reflexes ontogeny and metabolic parameters of offspring mice

Abstract

Maternal exposure to a Western type diet during pregnancy might predispose the offspring to manifestation of metabolic and behavioral disturbances in later life. Western type diet contains large amounts of advanced glycation end products (AGEs). In humans and experimental rodents, intake of AGEs rich diet (AGE-RD) negatively affected glucose homeostasis, and initiated the production of reactive oxygen species. Rats consuming AGE-RD presented changes in behavior. It remains unclear whether maternal intake of AGE-RD might affect developmental plasticity in offspring. We examined early somatic (weight, incisor eruption, ear unfolding, eye opening) and neuromotor development, oxidative status, insulin sensitivity (HOMA index) and locomotor activity assessed in PhenoTyper cages in the offspring of mice fed during pregnancy with either AGE-RD (25% bread crusts/75% control chow) or control chow. Till weaning, somatic development of offspring did not differ between two dietary groups. AGE-RD offspring manifested physiological reflexes (auditory startle, eye lid, ear twitch and righting reflexes) earlier. As young adults, male offspring of AGE-RD dams were heavier and less insulin sensitive compared with their control counterparts. AGE-RD offspring showed higher locomotor activity during the active phase. Our data indicate that maternal AGE-RD during pregnancy might accelerate the maturation of reflexes in offspring, predispose the male progeny to weight gain and affect their glucose homeostasis. These effects manifest without the direct consumption of AGE-RD by offspring. Further work is needed to determine the mechanisms by which maternal AGE-RD affects neurobehavioral pathways in offspring, as well as sex differences in adverse metabolic responses.

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Publication details

The article was received on 27 Jan 2018, accepted on 15 May 2018 and first published on 16 May 2018


Article type: Paper
DOI: 10.1039/C8FO00183A
Citation: Food Funct., 2018, Accepted Manuscript
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    The effects of maternal advanced glycation end products-rich diet on somatic features, reflexes ontogeny and metabolic parameters of offspring mice

    M. Csongova, R. Gurecka, I. Koborova, P. Celec, E. Domonkos, O. Ulicna, V. Somoza and K. Sebekova, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO00183A

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