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Issue 5, 2018
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Resveratrol reverses the adverse effects of a diet-induced obese murine model on oocyte quality and zona pellucida softening

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Abstract

Reproductive dysfunction associated with obesity is increasing among women of reproductive age, including infertility and increasing risk of miscarriage. In females, reproductive disorders are linked to declining quality of oocytes. Using a model of diet-induced obesity, we have investigated the possible effects of obesity on oocyte quality, including metabolism, lipid accumulation, ROS levels, meiosis and changes in spindle structure in Metaphase II. Our study showed that obesity induced by a high fat diet can impair oocyte meiosis, destroy spindle assembly, and promote oxidative stress and abnormal mitochondrial distribution. With the addition of resveratrol, the negative impact of diet-induced obesity on the quality of oocytes was alleviated to some extent. In addition, we found that obesity causes mouse oocytes to soften, and resveratrol can restore the zona pellucida of oocytes to the same state as the control group. In conclusion, resveratrol can reverse the adverse effects of obesity on oocytes, which is beneficial for subsequent embryonic development.

Graphical abstract: Resveratrol reverses the adverse effects of a diet-induced obese murine model on oocyte quality and zona pellucida softening

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The article was received on 23 Jan 2018, accepted on 02 Apr 2018 and first published on 09 Apr 2018


Article type: Paper
DOI: 10.1039/C8FO00149A
Citation: Food Funct., 2018,9, 2623-2633
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    Resveratrol reverses the adverse effects of a diet-induced obese murine model on oocyte quality and zona pellucida softening

    Z. Jia, Z. Feng, L. Wang, H. Li, H. Wang, D. Xu, X. Zhao, D. Feng and X. Feng, Food Funct., 2018, 9, 2623
    DOI: 10.1039/C8FO00149A

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