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Stress resistance and lifespan extension of Caenorhabditis elegans enhanced by peptides from mussel (Mytilus edulis) protein hydrolyzate

Abstract

Bioactive peptides derived from mussel have multiple healthcare functions. We here aimed to examine the effects of mussel peptide preparation on lifespan, stress resistance, apoptosis and aging in Caenorhabditis elegans. Lifespan was determined by counting the number of surviving nematodes daily. ROS level and lipofuscin were measured using a fluorescent microscope. The mussel protein was prepared and hydrolyzed, and then fractionated by ultrafiltration. The fraction (<3 kDa) was purified by gel filtration to obtain the bioactive peptides and peptide sequences included in fractions were identified, which were mostly composed of peptides with <20 amino acid residues. Mussel peptides treatment was found to significantly increase oxidative stress resistance and extend lifespan of C. elegans. Moreover, it also reduced endogenous ROS level and aging pigments accumulation in C. elegans, as well as apoptosis. Taken together, these findings demonstrated that mussel peptides could contribute to healthspan extension of C. elegans through regulating mRNA expression of daf-2 and daf-16. These results highlighted the important role of mussel peptides for food and pharmaceutical industries to develop new nutraceuticals and functional foods.

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Publication details

The article was received on 04 Jan 2018, accepted on 07 May 2018 and first published on 08 May 2018


Article type: Paper
DOI: 10.1039/C8FO00021B
Citation: Food Funct., 2018, Accepted Manuscript
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    Stress resistance and lifespan extension of Caenorhabditis elegans enhanced by peptides from mussel (Mytilus edulis) protein hydrolyzate

    Y. Zhou, Q. Xu, X. H. Zhou, S. Song and B. Zhu, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO00021B

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