Jump to main content
Jump to site search


Citrus peel extracts attenuated obesity and modulated gut microbiota in a high-fat diet-induced obesity mice

Abstract

Obesity is a serious health issue worldwide. Polymethoxyflavones (PMFs) and hydroxyl PMFs (HOPMFs) are mainly found in citrus peel and have shown their anti-obesity ability both in vitro and in vivo. In this study, we investigated the anti-obesity effects of two citrus peel extracts (PMF A and PMF B) prepared by supercritical fluid extraction in a high fat diet (HFD)-induced obese animal model for 16 weeks. The results showed that PMF B, which has higher contents of PMFs and HOPMFs, decreased lipid content in 3T3-L1 preadipocytes and alleviated body weight gain, white adipose tissue weight, and a dipocyte size in HFD-induced obese mice more than PMF A. Both PMF A and PMF B reduced the adipocyte size in perigonadal fat by markedly decreasing the levels of lipid droplets (LD) protein perilipin 1 and Sterol regulatory element binding protein 1 (SREBP-1) protein. Interestingly, comparing to HFD group, PMF B altered the gut microbiota abundance by increasing Prevotella and decreasing rc4-4. Taken together, our results suggested that citrus peel extracts decreased lipid accumulation both in vivo and in vitro. Therefore, citrus peel extracts could be considered as a nutraceutical agent for obesity management.

Back to tab navigation

Supplementary files

Publication details

The article was received on 28 Dec 2017, accepted on 10 May 2018 and first published on 14 May 2018


Article type: Paper
DOI: 10.1039/C7FO02066J
Citation: Food Funct., 2018, Accepted Manuscript
  •   Request permissions

    Citrus peel extracts attenuated obesity and modulated gut microbiota in a high-fat diet-induced obesity mice

    Y. Tung, W. Chang, S. Li, J. Wu, V. Badmeav, C. Ho and M. Pan, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C7FO02066J

Search articles by author

Spotlight

Advertisements