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Inhibitory effects of catechins on β-carbolines in tea leaves and chemical model systems


The profile of 18 heterocyclic amines from seven categories (including β-carbolines) in tea leaves during green and black tea processing procedures, as well as commercial tea products was screened by ultrahigh-performance liquid chromatography with tandem mass spectrometry. The 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), and 2-amino-3,8-dimethyl-imidazo[4,5-f]quinoxaline (MeIQx) were detected in samples; however, the levels were too low for quantification. The β-carboline compounds harman and norharman were quantified in all the samples. During processing, both harman and norharman levels increased significantly (p < 0.01) with the highest levels present in tea leaves during rolling stage of green tea processing and drying stage of black tea processing. In commercial products, the highest levels of harman and norharman were found in black tea as 31.49 ± 3.21 and 59.68 ± 4.71 ng/g sample, respectively. In combination with catechins levels of tea leaves and the results of chemical model systems, it was demonstrated that ECG, EGC, and EGCG could significantly (p < 0.01) inhibit the formation of harman and norharman by up to 45% and 52%, respectively.

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Publication details

The article was received on 26 Dec 2017, accepted on 29 Apr 2018 and first published on 30 Apr 2018

Article type: Paper
DOI: 10.1039/C7FO02053H
Citation: Food Funct., 2018, Accepted Manuscript
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    Inhibitory effects of catechins on β-carbolines in tea leaves and chemical model systems

    Y. Jiao, Y. Yan, Z. HE, D. Gao, F. Qin, M. Lu, M. Xie, J. Chen and M. Zeng, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C7FO02053H

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