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Issue 3, 2018
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Grape seed proanthocyanidins influence gut microbiota and enteroendocrine secretions in female rats

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Abstract

Grape seed proanthocyanidin extract (GSPE) modulates several parameters involved in metabolic syndrome. GSPE is a mixture of compounds, some which are rapidly absorbed, while others remain in the lumen where they might have effects that are translated to the whole organism. Our aim was to decipher if the 8-day treatment of GSPE, previously shown to reduce food intake, induces changes in the microbiota and enterohormone secretion. The ratio of Firmicutes : Bacteroidetes was lower in the microbiota of GSPE-treated rats compared to controls, and differences in several taxonomic families and genera were observed. Such modulation led to a reduction in cecal butyrate content. GSPE also increased plasma glucagon-like-peptide-1 (GLP-1). Gallic acid did not induce major changes in the microbiota profile nor in GLP-1 secretion. Correlations between several microbiota taxa and plasma triacylglycerol, adiposity, and enterohormones were observed. Modulation of microbiota may be one of the mechanism by which GSPE impacts metabolic health.

Graphical abstract: Grape seed proanthocyanidins influence gut microbiota and enteroendocrine secretions in female rats

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Publication details

The article was received on 22 Dec 2017, accepted on 11 Feb 2018 and first published on 20 Feb 2018


Article type: Paper
DOI: 10.1039/C7FO02028G
Citation: Food Funct., 2018,9, 1672-1682
  • Open access: Creative Commons BY-NC license
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    Grape seed proanthocyanidins influence gut microbiota and enteroendocrine secretions in female rats

    À. Casanova-Martí, J. Serrano, K. J. Portune, Y. Sanz, M. T. Blay, X. Terra, A. Ardévol and M. Pinent, Food Funct., 2018, 9, 1672
    DOI: 10.1039/C7FO02028G

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