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Effects of dietary β-glucan supplementation on growth performance, immunological and metabolic parameters of weaned pigs challenged with Escherichia coli lipopolysaccharide

Abstract

This objective of the study was to determine the effects of dietary β-glucan (BG) on growth performance and blood parameters in weaned pigs challenged with Escherichia coli lipopolysaccharide (LPS). Twenty-four pigs [(24±2 days old; 6.60±0.04 kg body weight (BW)]were randomly allocated into two groups (12 pigs/group) with diets supplemented with 0 or BG at 200 mg/kg diet (CON vs. BG). These pigs were fed for a 35-day trial. On d 36, six pigs from CON and BG were intramuscularly challenged with LPS (50 µg/kg), respectively, while another 6 pigs from CON intramuscularly challenged with an equivalent amount of sterile saline. Blood samples were collected at 3 h and rectal temperature data were collected at 0, 4, 8 and 24 h after LPS challenge. The results showed that pigs fed BG diet had increased average daily gain during week 4, week 5 and the overall period compared with pigs fed CON diet (P < 0.05), and resulted in greater final BW (P < 0.05). LPS challenge increased the rectal temperature of pigs fed CON diet at 4, 8 and 24 h post-challenge (P < 0.05), also increased the serum concentrations of pig major acute phase protein, haptoglobin, tumor necrosis factor-α and interleukine-1 beta (P < 0.05). However, the pigs fed BG diet had higher concentration of serum complement 3 (P < 0.05) and lower concentration of serum Pig-MAP, HP and interleuking-6 (P = 0.08) than that of pigs fed CON diet after LPS-challenge. Relative to the non-challenged pigs, moreover, LPS challenge increased the concentrations of serum creatinine, direct bilirubin and some of the amino acids in pigs with LPS-challenge (P < 0.05). In conclusion, the study suggested that pigs fed BG diet could improve growth performance and partially alleviated the inflammation response after LPS challenge.

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Publication details

The article was received on 16 Dec 2017, accepted on 11 May 2018 and first published on 14 May 2018


Article type: Paper
DOI: 10.1039/C7FO01980G
Citation: Food Funct., 2018, Accepted Manuscript
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    Effects of dietary β-glucan supplementation on growth performance, immunological and metabolic parameters of weaned pigs challenged with Escherichia coli lipopolysaccharide

    C. Wu, Q. Xu, R. Wang, X. Peng, L. Qing, L. Hu, Y. Liu, Z. Fang, Y. Lin, S. Xu, B. Feng, J. Li, D. Wu and L. Che, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C7FO01980G

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