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Ultrasound-assisted aqueous extraction, LC-MS/MS Analysis and Radiomodulating Capability of Autochthonous Italian Sweet Cherry fruits

Abstract

The current cancer treatment scenario lacks drugs acting as both radiosensitizer and radioprotector agents. In this context, the radiomodulatory properties exerted by an aqueous extract from fruits of the Italian Prunus avium cv. Della Recca (PaDRw) were investigated. The extract, obtained through an environmental-friendly ultrasound-assisted extraction, seemed to act as radioprotector at lower tested doses (25 and 50 μg/mL) and radiosensitizer at 400 and 500 μg/mL dose levels towards neuroblastoma SH-SY5Y cell line, irradiated with four graded x-ray doses (0, 0.5, 2, and 4 Gy). The fractionation of PaDRw by Amberlite XAD-4 non-ionic polymeric resin, coupled to LC-UV-MS/MS techniques, proved to be efficient also in the disclosure of lower constituents. About 63% of the whole PaDRw extract was constituted by hexitol, followed by fructose (~22.8%) and glucose (~10.7%). Chlorogenic acids and flavonoids, which accounted only for ~2.2%, were hypothesized to be the main actors in PaDRw-induced radiomodulation.

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Supplementary files

Publication details

The article was received on 15 Dec 2017, accepted on 09 Feb 2018 and first published on 13 Feb 2018


Article type: Paper
DOI: 10.1039/C7FO01977G
Citation: Food Funct., 2018, Accepted Manuscript
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    Ultrasound-assisted aqueous extraction, LC-MS/MS Analysis and Radiomodulating Capability of Autochthonous Italian Sweet Cherry fruits

    S. Piccolella, G. Crescente, P. Nocera, F. Pacifico, L. Manti and S. Pacifico, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C7FO01977G

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