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Issue 4, 2018
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Citrus reticulata peel oil inhibits non-small cell lung cancer cell proliferation in culture and implanted in nude mice

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Abstract

Non-small cell lung cancer (NSCLC) accounts for most cases of lung cancer. The peel oil of mandarin Citrus reticulata Blanco cv. Dancy (MPO) is a natural source of essential oils and carotenoids. Volatile and non-volatile lipid compounds were characterized by chromatographic methods. We demonstrate that MPO causes a dose-dependent growth inhibition of NSCLC model cells (A549) in culture and tumour growth in vivo of the same cells implanted in nude mice fed with MPO-supplemented diets. MPO induced cell cycle arrest mainly at the G0/G1 phase and reduced the amount of membrane-bound Ras protein along with apoptosis induction. No toxicological effect was found in liver parameters analysed in treated mice and histopathological analyses of their organs did not show any morphological changes. In conclusion, the data suggest that MPO possesses significant antitumor activity without causing systemic toxicity, proposing it as a dietary supplement that may be helpful in cancer prevention.

Graphical abstract: Citrus reticulata peel oil inhibits non-small cell lung cancer cell proliferation in culture and implanted in nude mice

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Publication details

The article was received on 04 Dec 2017, accepted on 26 Feb 2018 and first published on 05 Mar 2018


Article type: Paper
DOI: 10.1039/C7FO01912B
Citation: Food Funct., 2018,9, 2290-2299
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    Citrus reticulata peel oil inhibits non-small cell lung cancer cell proliferation in culture and implanted in nude mice

    M. A. Castro, B. Rodenak-Kladniew, A. Massone, M. Polo, M. García de Bravo and R. Crespo, Food Funct., 2018, 9, 2290
    DOI: 10.1039/C7FO01912B

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