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Monascin inhibits IL-1β induced catabolism in mouse chondrocytes and ameliorates murine osteoarthritis

Abstract

Osteoarthritis (OA) is an age-related degenerative disease and is the fourth major cause of disability, but without any effective therapies because of the complex pathology and drug itself side effects. Previous researches demonstrated that the inflammation and ECM degradation plays a major role in OA development. Monascin is an azaphilonoid pigment extracted from the Monascus-fermented rice with potential anti-inflammatory effect reported in various preclinical studies. In present study, we investigated the protectiveness of Monascin on interleukin (IL)-1β-induced mouse chondrocytes and surgical destabilization of the medial meniscus mouse (DMM) OA models. In vitro, Monascin treatment inhibited IL-1β-induced expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), Nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6). In addition, the IL-1β-stimulated matrix metalloproteinase-13 (MMP-13) and thrombospondin motifs 5 (ADAMTS-5) upregulation and type two collagen and aggrecan degradation was reversed by Monascin. Mechanistically, we revealed that Monascin suppressed nuclear factor kappa B (NF-κB) signaling by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in IL-1β-induced chondrocytes. And Monascin-induced protectiveness in OA development was also shown by DMM model. Taken together, our results suggested that Monascin could be a novel therapeutic approach for OA.

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Publication details

The article was received on 30 Nov 2017, accepted on 31 Jan 2018 and first published on 01 Feb 2018


Article type: Paper
DOI: 10.1039/C7FO01892D
Citation: Food Funct., 2018, Accepted Manuscript
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    Monascin inhibits IL-1β induced catabolism in mouse chondrocytes and ameliorates murine osteoarthritis

    G. Zheng, Y. Zhan, Q. Tang, T. Chen, F. Zheng, H. Wang, J. Wang, D. Wu, X. Li, Y. Zhou, X. Wang, Y. Wu, Y. Zhou, H. Xu, N. Tian and X. Zhang, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C7FO01892D

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