Jump to main content
Jump to site search

Issue 5, 2018
Previous Article Next Article

Multiple mechanisms applied by Lactobacillus pentosus AT6 to mute the lethal effects of Salmonella in a mouse model

Author affiliations

Abstract

Probiotics are now prevalent world-wide, as functional food supplements with many benefits for humans and animals, such as protective effects against pathogenic infection. We showed that oral supplementation of Lactobacillus pentosus AT6 (AT6) decreased the mortality rate of mice with Salmonella infection. A series of experiments showed that the protective effects of AT6 on mice involved multiple mechanisms, including (1) the inhibition of Salmonella Typhimurium growth by AT6 or its cell-free culture supernatants (CFCSs); (2) the reduction of the bacterial loads of Salmonella Typhimurium in intestinal contents and internal organs, such as the liver and spleen; (3) the inhibition of adhesion and invasion of Salmonella Typhimurium into intestinal epithelial cells; and (4) the regulation of host immunities by modifying the production of a chain of cytokines. In conclusion, AT6 inhibited Salmonella infection via multiple mechanisms and therefore has great potential for the development of functional foods with anti-Salmonella activities.

Graphical abstract: Multiple mechanisms applied by Lactobacillus pentosus AT6 to mute the lethal effects of Salmonella in a mouse model

Back to tab navigation

Publication details

The article was received on 23 Nov 2017, accepted on 29 Mar 2018 and first published on 02 Apr 2018


Article type: Paper
DOI: 10.1039/C7FO01858D
Citation: Food Funct., 2018,9, 2787-2795
  •   Request permissions

    Multiple mechanisms applied by Lactobacillus pentosus AT6 to mute the lethal effects of Salmonella in a mouse model

    J. Liu, Z. Gu, W. Lu, D. Hu, X. Zhao, H. Huang, H. Zhang, J. Zhao and W. Chen, Food Funct., 2018, 9, 2787
    DOI: 10.1039/C7FO01858D

Search articles by author

Spotlight

Advertisements